Total Synthesis of Highly Symmetric Squalene-Derived Cytotoxic Polyethers.
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چکیده
منابع مشابه
Total syntheses of the squalene-derived halogenated polyethers ent-dioxepandehydrothyrsiferol and armatol A via bromonium- and Lewis acid-initiated epoxide-opening cascades.
Herein we describe in full our investigations leading to the first total syntheses of ent-dioxepandehydrothyrsiferol and armatol A. Discovery of a bromonium-initiated epoxide-opening cascade enabled novel tactics for constructing key fragments found in both natural products and have led us to revise the proposed biogeneses. Other common features found in the routes include convergent fragment c...
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10 H. Beinert and P. G. Stansly, J. Biol. Chem., 204, 67, 1953. 1 D. E. Green, D. S. Goldman, S. Mii, and H. Beinert, J. Biol. Chem., 202, 137, 1953. 12 E. R. Stadtman and H. A. Barker, J. Biol. Chem., 184, 769, 1950. '3 E. R. Stadtman, J. Biol. Chem., 196, 535, 1952. 14 A. A. Benson, J. A. Bassham, M. Calvin, T. C. Goodale, V. A. Haas, and W. Stepka, J. Am. Chem. Soc., 72, 1710, 1950. 15 F. Ly...
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ژورنال
عنوان ژورنال: Journal of Synthetic Organic Chemistry, Japan
سال: 2002
ISSN: 0037-9980,1883-6526
DOI: 10.5059/yukigoseikyokaishi.60.1112